Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel

PURPOSE: Docetaxel is extensively metabolized by CYP3A4 in the liver, but mechanisms by which the drug is taken up into hepatocytes remain poorly understood. We hypothesized that (i) liver uptake of docetaxel is mediated by the polymorphic solute carriers OATP1B1 and OATP1B3, and (ii) that inherited...

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Detalhes bibliográficos
Main Authors: de Graan, Anne-Joy M., Lancaster, Cynthia S., Obaidat, Amanda, Hagenbuch, Bruno, Elens, Laure, Friberg, Lena E., de Bruijn, Peter, Hu, Shuiying, Gibson, Alice A., Bruun, Gitte H., Corydon, Thomas J., Mikkelsen, Torben S., Walker, Aisha L., Du, Guoqing, Loos, Walter J., van Schaik, Ron H. N., Baker, Sharyn D., Mathijssen, Ron H. J., Sparreboom, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464009/
https://ncbi.nlm.nih.gov/pubmed/22711709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0761
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