Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel

PURPOSE: Docetaxel is extensively metabolized by CYP3A4 in the liver, but mechanisms by which the drug is taken up into hepatocytes remain poorly understood. We hypothesized that (i) liver uptake of docetaxel is mediated by the polymorphic solute carriers OATP1B1 and OATP1B3, and (ii) that inherited...

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Main Authors: de Graan, Anne-Joy M., Lancaster, Cynthia S., Obaidat, Amanda, Hagenbuch, Bruno, Elens, Laure, Friberg, Lena E., de Bruijn, Peter, Hu, Shuiying, Gibson, Alice A., Bruun, Gitte H., Corydon, Thomas J., Mikkelsen, Torben S., Walker, Aisha L., Du, Guoqing, Loos, Walter J., van Schaik, Ron H. N., Baker, Sharyn D., Mathijssen, Ron H. J., Sparreboom, Alex
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464009/
https://ncbi.nlm.nih.gov/pubmed/22711709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0761
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