Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

PURPOSE: Taxane antineoplastic agents are extensively taken up into hepatocytes by OATP1B-type transporters prior to metabolism and excretion. Because the biodistributional properties imposed upon these agents by different solubilizers drive clinically-important pharmacodynamic endpoints, we tested...

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Main Authors: Nieuweboer, Annemieke J.M., Hu, Shuiying, Hagenbuch, Bruno, Moghaddam-Helmantel, Inge Ghobadi, Gibson, Alice A., de Bruijn, Peter, Mathijssen, Ron H. J., Sparreboom, Alex
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161133/
https://ncbi.nlm.nih.gov/pubmed/24755470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3634
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