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Dependence of erythromycin metabolism on ABCC2 (MRP2) transport function

The macrolide antiobiotic erythromycin undergoes extensive hepatic metabolism and is commonly used as a probe for CYP3A4 activity. Using a transporter screen, erythromycin was identified as a substrate for the transporter ABCC2 (MRP2) and its murine ortholog, Abcc2. Since these proteins are highly e...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Franke, RM, Lancaster, CS, Peer, CJ, Gibson, A, Kosloske, AM, Orwick, SJ, Mathijssen, RH, Figg, WD, Baker, SD, Sparreboom, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519823/
https://ncbi.nlm.nih.gov/pubmed/21451505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.25
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