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Association of ABCC2 polymorphisms with cisplatin disposition and efficacy
ABCC2 (MRP2; cMOAT) expression has been implicated in cisplatin resistance in vitro. In mice, cisplatin disposition and toxicity were unaffected by Abcc2 knockout. Moreover, in cancer patients (n=237), cisplatin pharmacokinetics (P>0.12) and efficacy (P>0.41) were not associated with 7 SNPs in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482956/ https://ncbi.nlm.nih.gov/pubmed/22534871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.330 |
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