Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones

by Pan, Xiao-Su, Fisher, L. Mark
Published 1999

DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae

by Pan, Xiao-Su, Fisher, L. Mark
Published 1998

Quinolone Resistance Mutations in Streptococcus pneumoniae GyrA and ParC Proteins: Mechanistic Insights into Quinolone Action from Enzymatic Analysis, Intracellular Levels, and Ph...

by Pan, Xiao-Su, Yague, Genoveva, Fisher, L. Mark
Published 2001

Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases

by Arnoldi, Elisa, Pan, Xiao-Su, Fisher, L Mark
Published 2013

Grepafloxacin, a Dimethyl Derivative of Ciprofloxacin, Acts Preferentially through Gyrase in Streptococcus pneumoniae: Role of the C-5 Group in Target Specificity

by Morris, Julia E., Pan, Xiao-Su, Fisher, L. Mark
Published 2002

Probing the Differential Interactions of Quinazolinedione PD 0305970 and Quinolones with Gyrase and Topoisomerase IV

by Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
Published 2009

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

by Pan, Xiao Su, Dias, Miriam, Palumbo, Manlio, Fisher, L. Mark
Published 2008

Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity

by Aubry, Alexandra, Pan, Xiao-Su, Fisher, L. Mark, Jarlier, Vincent, Cambau, Emmanuelle
Published 2004

Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae

by Gould, Katherine A., Pan, Xiao-Su, Kerns, Robert J., Fisher, L. Mark
Published 2004

Cleavable-Complex Formation by Wild-Type and Quinolone-Resistant Streptococcus pneumoniae Type II Topoisomerases Mediated by Gemifloxacin and Other Fluoroquinolones

by Yague, Genoveva, Morris, Julia E., Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
Published 2002

Engineering the Specificity of Antibacterial Fluoroquinolones: Benzenesulfonamide Modifications at C-7 of Ciprofloxacin Change Its Primary Target in Streptococcus pneumoniae from...

by Alovero, Fabiana L., Pan, Xiao-Su, Morris, Julia E., Manzo, Ruben H., Fisher, L. Mark
Published 2000

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

by Sohi, Maninder K., Veselkov, Dennis A., Laponogov, Ivan, Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Published 2008

Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

by Laponogov, Ivan, Veselkov, Dennis A., Crevel, Isabelle M.-T., Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Published 2013

Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones

by Pan, Xiao-Su, Hamlyn, Penelope J., Talens-Visconti, Raquel, Alovero, Fabiana L., Manzo, Ruben H., Fisher, L. Mark
Published 2002

Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

by Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., McAuley, Katherine E., Fisher, L. Mark, Sanderson, Mark R.
Published 2010

Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

by Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., McAuley, Katherine E., Fisher, L. Mark, Sanderson, Mark R.
Published 2010

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

by Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., McAuley, Katherine E., Fisher, L. Mark, Sanderson, Mark R.
Published 2010

Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase

by Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., Skamrova, Galyna B., Umrekar, Trishant R., Fisher, L. Mark, Sanderson, Mark R.
Published in Nat Commun (2018)

Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

by Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., Cirz, Ryan T., Wagman, Allan, Moser, Heinz E., Fisher, L. Mark, Sanderson, Mark R.
Published in Open Biol (2016)

Breakage-Reunion Domain of Streptococcus pneumoniae Topoisomerase IV: Crystal Structure of a Gram-Positive Quinolone Target

by Laponogov, Ivan, Veselkov, Dennis A., Sohi, Maninder K., Pan, Xiao-Su, Achari, Aniruddha, Yang, Cheng, Ferrara, Joseph D., Fisher, L. Mark, Sanderson, Mark R.
Published 2007