लोड हो रहा है...
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood. We establish by genetic means that CL targets DNA gyrase in the Gram-positive bacterium Streptococcus pneu...
में बचाया:
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553588/ https://ncbi.nlm.nih.gov/pubmed/18723572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn539 |
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