Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones

Por Pan, Xiao-Su, Fisher, L. Mark
Publicado em 1999

DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae

Por Pan, Xiao-Su, Fisher, L. Mark
Publicado em 1998

Quinolone Resistance Mutations in Streptococcus pneumoniae GyrA and ParC Proteins: Mechanistic Insights into Quinolone Action from Enzymatic Analysis, Intracellular Levels, and Ph...

Por Pan, Xiao-Su, Yague, Genoveva, Fisher, L. Mark
Publicado em 2001

Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases

Por Arnoldi, Elisa, Pan, Xiao-Su, Fisher, L Mark
Publicado em 2013

Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilizati...

Por Heaton, Victoria J., Ambler, Jane E., Fisher, L. Mark
Publicado em 2000

Grepafloxacin, a Dimethyl Derivative of Ciprofloxacin, Acts Preferentially through Gyrase in Streptococcus pneumoniae: Role of the C-5 Group in Target Specificity

Por Morris, Julia E., Pan, Xiao-Su, Fisher, L. Mark
Publicado em 2002

Probing the Differential Interactions of Quinazolinedione PD 0305970 and Quinolones with Gyrase and Topoisomerase IV

Por Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
Publicado em 2009

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

Por Pan, Xiao Su, Dias, Miriam, Palumbo, Manlio, Fisher, L. Mark
Publicado em 2008

Activity of Gemifloxacin against Penicillin- and Ciprofloxacin-Resistant Streptococcus pneumoniae Displaying Topoisomerase- and Efflux-Mediated Resistance Mechanisms

Por Heaton, Victoria J., Goldsmith, Colin E., Ambler, Jane E., Fisher, L. Mark
Publicado em 1999

Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity

Por Aubry, Alexandra, Pan, Xiao-Su, Fisher, L. Mark, Jarlier, Vincent, Cambau, Emmanuelle
Publicado em 2004

Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae

Por Gould, Katherine A., Pan, Xiao-Su, Kerns, Robert J., Fisher, L. Mark
Publicado em 2004

Cleavable-Complex Formation by Wild-Type and Quinolone-Resistant Streptococcus pneumoniae Type II Topoisomerases Mediated by Gemifloxacin and Other Fluoroquinolones

Por Yague, Genoveva, Morris, Julia E., Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
Publicado em 2002

Novel Gyrase Mutations in Quinolone-Resistant and -Hypersusceptible Clinical Isolates of Mycobacterium tuberculosis: Functional Analysis of Mutant Enzymes

Por Aubry, Alexandra, Veziris, Nicolas, Cambau, Emmanuelle, Truffot-Pernot, Chantal, Jarlier, Vincent, Fisher, L. Mark
Publicado em 2006

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage

Por Richter, Sara N., Leo, Elisabetta, Giaretta, Giulia, Gatto, Barbara, Fisher, L. Mark, Palumbo, Manlio
Publicado em 2006

Engineering the Specificity of Antibacterial Fluoroquinolones: Benzenesulfonamide Modifications at C-7 of Ciprofloxacin Change Its Primary Target in Streptococcus pneumoniae from...

Por Alovero, Fabiana L., Pan, Xiao-Su, Morris, Julia E., Manzo, Ruben H., Fisher, L. Mark
Publicado em 2000

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

Por Sohi, Maninder K., Veselkov, Dennis A., Laponogov, Ivan, Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Publicado em 2008

Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

Por Laponogov, Ivan, Veselkov, Dennis A., Crevel, Isabelle M.-T., Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Publicado em 2013

Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones

Por Pan, Xiao-Su, Hamlyn, Penelope J., Talens-Visconti, Raquel, Alovero, Fabiana L., Manzo, Ruben H., Fisher, L. Mark
Publicado em 2002

Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

Por Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., McAuley, Katherine E., Fisher, L. Mark, Sanderson, Mark R.
Publicado em 2010

Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

Por Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., McAuley, Katherine E., Fisher, L. Mark, Sanderson, Mark R.
Publicado em 2010