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Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage

Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CL action in the presence of topoisomerase IV from Streptococcus pneumoniae. CL promoted irreversible enzyme-mediated DNA cleavage lead...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Richter, Sara N., Leo, Elisabetta, Giaretta, Giulia, Gatto, Barbara, Fisher, L. Mark, Palumbo, Manlio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2006
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435983/
https://ncbi.nlm.nih.gov/pubmed/16614448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl127
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