Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage

Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CL action in the presence of topoisomerase IV from Streptococcus pneumoniae. CL promoted irreversible enzyme-mediated DNA cleavage lead...

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Autores principales: Richter, Sara N., Leo, Elisabetta, Giaretta, Giulia, Gatto, Barbara, Fisher, L. Mark, Palumbo, Manlio
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435983/
https://ncbi.nlm.nih.gov/pubmed/16614448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl127
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