Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase–quinolone complexes. A careful statistical analysis of...

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Detalhes bibliográficos
Main Authors: Richter, Sara N., Giaretta, Giulia, Comuzzi, Valentina, Leo, Elisabetta, Mitchenall, Lesley A., Fisher, L. Mark, Maxwell, Anthony, Palumbo, Manlio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094056/
https://ncbi.nlm.nih.gov/pubmed/17766248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm653
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