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Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DNA. Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-ion mechanism to promote DNA scission. However, the role of metal...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113566/ https://ncbi.nlm.nih.gov/pubmed/21300644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr018 |
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