Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

It has long been known that type II topoisomerases require divalent metal ions in order to cleave DNA. Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-ion mechanism to promote DNA scission. However, the role of metal...

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Hlavní autoři: Pitts, Steven L., Liou, Grace F., Mitchenall, Lesley A., Burgin, Alex B., Maxwell, Anthony, Neuman, Keir C., Osheroff, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113566/
https://ncbi.nlm.nih.gov/pubmed/21300644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr018
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