Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

It has long been known that type II topoisomerases require divalent metal ions in order to cleave DNA. Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-ion mechanism to promote DNA scission. However, the role of metal...

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Bibliografiset tiedot
Päätekijät: Pitts, Steven L., Liou, Grace F., Mitchenall, Lesley A., Burgin, Alex B., Maxwell, Anthony, Neuman, Keir C., Osheroff, Neil
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2011
Aiheet:
Nucleic Acid Enzymes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113566/
https://ncbi.nlm.nih.gov/pubmed/21300644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr018
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