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Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage
The DNA cleavage reaction of human topoisomerase IIα is critical to all of the physiological and pharmacological functions of the protein. While it has long been known that the type II enzyme requires a divalent metal ion in order to cleave DNA, the role of the cation in this process is not known. T...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528187/ https://ncbi.nlm.nih.gov/pubmed/18653531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn466 |
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