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Metal Ion Interactions in the DNA Cleavage/Ligation Active Site of Human Topoisomerase IIα
Human topoisomerase IIα utilizes a two-metal-ion mechanism for DNA cleavage. One of the metal ions (M(1)(2+)) is believed to make a critical interaction with the 3′-bridging atom of the scissile phosphate, while the other (M(2)(2+)) is believed to interact with a non-bridging oxygen of the scissile...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782489/ https://ncbi.nlm.nih.gov/pubmed/19697956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900875c |
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