Cargando...

Coordinating the Two Protomer Active Sites of Human Topoisomerase IIα: Nicks as Topoisomerase II Poisons

Topoisomerase II modulates DNA topology by generating double-stranded breaks in DNA. Results of the current study indicate that the presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIα at the scissile bond on the opposite strand. We propose t...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Deweese, Joseph E., Osheroff, Neil
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716134/
https://ncbi.nlm.nih.gov/pubmed/19166355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8021679
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!