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Coordinating the Two Protomer Active Sites of Human Topoisomerase IIα: Nicks as Topoisomerase II Poisons

Topoisomerase II modulates DNA topology by generating double-stranded breaks in DNA. Results of the current study indicate that the presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIα at the scissile bond on the opposite strand. We propose t...

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Hlavní autoři: Deweese, Joseph E., Osheroff, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716134/
https://ncbi.nlm.nih.gov/pubmed/19166355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8021679
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