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A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
Type II topoisomerases are required for the management of DNA tangles and supercoils1, and are targets of clinical antibiotics and anti-cancer agents2. These enzymes catalyze the ATP-dependent passage of one DNA duplex (the transport or T-segment) through a transient, double-stranded break in anothe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882514/ https://ncbi.nlm.nih.gov/pubmed/20485342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08974 |
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