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The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I

Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events m...

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Библиографические подробности
Главные авторы: Gentry, Amanda C., Juul, Sissel, Veigaard, Christopher, Knudsen, Birgitta R., Osheroff, Neil
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035449/
https://ncbi.nlm.nih.gov/pubmed/20855291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq822
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