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The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events m...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035449/ https://ncbi.nlm.nih.gov/pubmed/20855291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq822 |
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