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Geometry of DNA Supercoils Modulates Topoisomerase-mediated DNA Cleavage and Enzyme Response to Anticancer Drugs
Collisions with DNA tracking systems are critical for the conversion of transient topoisomerase-DNA cleavage complexes to permanent strand breaks. Since DNA is overwound ahead of tracking systems, cleavage complexes most likely to produce permanent strand breaks should be formed between topoisomeras...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517258/ https://ncbi.nlm.nih.gov/pubmed/16503659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051987q |
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