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Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases
Antibacterial fluoroquinolones trap a cleavage complex of gyrase and topoisomerase (topo) IV inducing site-specific DNA breakage within a bent DNA gate engaged in DNA transport. Despite its importance for drug action and in revealing potential sites of topoisomerase catalysis, the mechanism of DNA s...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814380/ https://ncbi.nlm.nih.gov/pubmed/23939623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt696 |
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