Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods

Por Fenner, Amanda M., Kerns, Robert J.
Publicado em 2011

Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system

Por Rosen, Jonathan D., German, Nadezhda, Kerns, Robert J.
Publicado em 2009

Mechanism of Quinolone Action and Resistance

Por Aldred, Katie J., Kerns, Robert J., Osheroff, Neil
Publicado em 2014

N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3

Por Craciun, Ioana, Fenner, Amanda M, Kerns, Robert J
Publicado no Glycobiology (2016)

Quinolone-Mediated Bacterial Death

Por Drlica, Karl, Malik, Muhammad, Kerns, Robert J., Zhao, Xilin
Publicado em 2008

Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure

Por Malik, Muhammad, Hoatam, Gerard, Chavda, Kalyan, Kerns, Robert J., Drlica, Karl
Publicado em 2010

Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl O-Sulfonated Aminoglycoside Derivatives

Por Fenner, Amanda M., Oppegard, Lisa M., Hiasa, Hiroshi, Kerns, Robert J.
Publicado em 2013

Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae

Por Gould, Katherine A., Pan, Xiao-Su, Kerns, Robert J., Fisher, L. Mark
Publicado em 2004

Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

Por German, Nadezhda, Malik, Muhammad, Rosen, Jonathan D., Drlica, Karl, Kerns, Robert J.
Publicado em 2008

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

Por Blower, Tim R., Williamson, Benjamin H., Kerns, Robert J., Berger, James M.
Publicado no Proc Natl Acad Sci U S A (2016)

Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones

Por Marks, Kevin R., Malik, Muhammad, Mustaev, Arkady, Hiasa, Hiroshi, Drlica, Karl, Kerns, Robert J.
Publicado em 2011

Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics

Por Malik, Muhammad, Li, Liping, Zhao, Xilin, Kerns, Robert J., Berger, James M., Drlica, Karl
Publicado no J Antimicrob Chemother (2014)

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site

Por Oppegard, Lisa M., Schwanz, Heidi A., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
Publicado no Biochim Biophys Acta (2015)

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

Por Aldred, Katie J., Blower, Tim R., Kerns, Robert J., Berger, James M., Osheroff, Neil
Publicado no Proc Natl Acad Sci U S A (2016)

Effect of N-1/C-8 Ring Fusion and C-7 Ring Structure on Fluoroquinolone Lethality

Por Malik, Muhammad, Marks, Kevin R., Schwanz, Heidi A., German, Nadezhda, Drlica, Karl, Kerns, Robert J.
Publicado em 2010

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Por Aldred, Katie J., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Publicado em 2013

Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design

Por Drlica, Karl, Mustaev, Arkady, Towle, Tyrell R., Luan, Gan, Kerns, Robert J., Berger, James M.
Publicado no ACS Chem Biol (2014)

Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

Por Malik, Muhammad, Marks, Kevin R., Mustaev, Arkady, Zhao, Xilin, Chavda, Kalyan, Kerns, Robert J., Drlica, Karl
Publicado em 2011

Metabolic effects of a mitochondrial‐targeted coenzyme Q analog in high fat fed obese mice

Por Fink, Brian D., Guo, Deng Fu, Kulkarni, Chaitanya A., Rahmouni, Kamal, Kerns, Robert J., Sivitz, William I.
Publicado no Pharmacol Res Perspect (2017)

Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells

Por Fink, Brian D., Herlein, Judith A., Yorek, Mark A., Fenner, Amanda M., Kerns, Robert J., Sivitz, William I.
Publicado em 2012