Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives were compared with cognate fluoroquinolones by using cultured Mycobacterium smegmatis. Diones exhibited higher MIC value...

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Detalhes bibliográficos
Main Authors: Malik, Muhammad, Marks, Kevin R., Mustaev, Arkady, Zhao, Xilin, Chavda, Kalyan, Kerns, Robert J., Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088267/
https://ncbi.nlm.nih.gov/pubmed/21383100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00033-11
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