Enhancement of Fluoroquinolone Activity by C-8 Halogen and Methoxy Moieties: Action against a Gyrase Resistance Mutant of Mycobacterium smegmatis and a Gyrase-Topoisomerase IV Double Mutant of Staphylococcus aureus

The increasing prevalence of antibiotic resistance among bacterial pathogens prompted a microbiological study of fluoroquinolone structure-activity relationships with resistant mutants. Bacteriostatic and bactericidal activities for 12 fluoroquinolones were examined with a gyrase mutant of Mycobacte...

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Detalhes bibliográficos
Main Authors: Lu, Tao, Zhao, Xilin, Li, Xinying, Drlica-Wagner, Alex, Wang, Jian-Ying, Domagala, John, Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90720/
https://ncbi.nlm.nih.gov/pubmed/11557458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2703-2709.2001
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