Enhancement of Fluoroquinolone Activity by C-8 Halogen and Methoxy Moieties: Action against a Gyrase Resistance Mutant of Mycobacterium smegmatis and a Gyrase-Topoisomerase IV Double Mutant of Staphylococcus aureus

The increasing prevalence of antibiotic resistance among bacterial pathogens prompted a microbiological study of fluoroquinolone structure-activity relationships with resistant mutants. Bacteriostatic and bactericidal activities for 12 fluoroquinolones were examined with a gyrase mutant of Mycobacte...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lu, Tao, Zhao, Xilin, Li, Xinying, Drlica-Wagner, Alex, Wang, Jian-Ying, Domagala, John, Drlica, Karl
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11557458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.10.2703-2709.2001
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