Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encou...

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Detalhes bibliográficos
Main Authors: Zhao, Xilin, Wang, Jian-Ying, Xu, Chen, Dong, Yuzhi, Zhou, Jianfeng, Domagala, John, Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105579/
https://ncbi.nlm.nih.gov/pubmed/9559820
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