Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance

Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In the present study, a C-8-methoxyl group improved bacteriostatic ac...

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Hlavní autoři: Dong, Yuzhi, Xu, Chen, Zhao, Xilin, Domagala, John, Drlica, Karl
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1998
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC105976/
https://ncbi.nlm.nih.gov/pubmed/9797236
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