Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance

Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In the present study, a C-8-methoxyl group improved bacteriostatic ac...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Dong, Yuzhi, Xu, Chen, Zhao, Xilin, Domagala, John, Drlica, Karl
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1998
Onderwerpen:	Mechanisms of Action: Physiological Effects
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105976/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9797236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.11.2978
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