Involvement of Holliday Junction Resolvase in Fluoroquinolone-Mediated Killing of Mycobacterium smegmatis

The absence of the Holliday-junction Ruv resolvase of Mycobacterium smegmatis increased the bacteriostatic and bactericidal activities of the fluoroquinolone moxifloxacin, an important antituberculosis agent. The treatment of ruvAB-deficient cells with thiourea and 2,2′-bipyridyl lowered moxifloxaci...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Long, Quanxin, Du, Qinglin, Fu, Tiwei, Drlica, Karl, Zhao, Xilin, Xie, Jianping
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325773/
https://ncbi.nlm.nih.gov/pubmed/25534729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04434-14
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items