Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol

Quinolones were examined for rapid lethal activity against Mycobacterium smegmatis in the presence and absence of chloramphenicol, an inhibitor of protein synthesis. C-8 methoxy, C-6 fluorine, and particular C-7 ring substituents enhanced rapid killing. With the surprising exception of moxifloxacin,...

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Detalhes bibliográficos
Main Authors: Malik, Muhammad, Lu, Tao, Zhao, Xilin, Singh, Anubha, Hattan, Christopher M., Domagala, John, Kerns, Robert, Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087661/
https://ncbi.nlm.nih.gov/pubmed/15855526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2008-2014.2005
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