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Fluoroquinolone-Gyrase-DNA Complexes: TWO MODES OF DRUG BINDING
DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex DNA through the break, and then resealing the break. This process is subject to reversible corruption by fluoroquinolones, antibacterials that form drug-enzyme-DNA complexes in which the DNA is broken. The...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007428/ https://ncbi.nlm.nih.gov/pubmed/24497635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529164 |
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