Replacement of ParC α4 Helix with That of GyrA Increases the Stability and Cytotoxicity of Topoisomerase IV-Quinolone-DNA Ternary Complexes

بواسطة Pfeiffer, Emily S., Hiasa, Hiroshi
منشور في 2004

Determination of the Primary Target of a Quinolone Drug and the Effect of Quinolone Resistance-Conferring Mutations by Measuring Quinolone Sensitivity Based on Its Mode of Action

بواسطة Pfeiffer, Emily S., Hiasa, Hiroshi
منشور في 2007

Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV–DNA complexes

بواسطة Shea, Molly E., Hiasa, Hiroshi
منشور في 2001

Bacillus cereus DNA topoisomerase I and IIIα: purification, characterization and complementation of Escherichia coli TopoIII activity

بواسطة Li, Zhiyu, Hiasa, Hiroshi, DiGate, Russell
منشور في 2005

Analysis of Pleiotropic Transcriptional Profiles: A Case Study of DNA Gyrase Inhibition

بواسطة Jeong, Kyeong Soo, Xie, Yang, Hiasa, Hiroshi, Khodursky, Arkady B
منشور في 2006

RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli

بواسطة Reckinger, Amy R., Jeong, Kyeong Soo, Khodursky, Arkady B., Hiasa, Hiroshi
منشور في 2007

Assessing Sensitivity to Antibacterial Topoisomerase II Inhibitors

بواسطة Morgan-Linnell, Sonia K., Hiasa, Hiroshi, Zechiedrich, Lynn, Nitiss, John L.
منشور في 2007

Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl O-Sulfonated Aminoglycoside Derivatives

بواسطة Fenner, Amanda M., Oppegard, Lisa M., Hiasa, Hiroshi, Kerns, Robert J.
منشور في 2013

Topoisomerases as Anticancer Targets

بواسطة Delgado, Justine L., Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi
الحاوية / القاعدة Biochem J (2018)

Quinolones: Action and Resistance Updated

بواسطة Drlica, Karl, Hiasa, Hiroshi, Kerns, Robert, Malik, Muhammad, Mustaev, Arkady, Zhao, Xilin
منشور في 2009

Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones

بواسطة Marks, Kevin R., Malik, Muhammad, Mustaev, Arkady, Hiasa, Hiroshi, Drlica, Karl, Kerns, Robert J.
منشور في 2011

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site

بواسطة Oppegard, Lisa M., Schwanz, Heidi A., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
الحاوية / القاعدة Biochim Biophys Acta (2015)

On the Role of Topoisomerase I in Mediating the Cytotoxicity of 9-Aminoacridine-Based Anticancer Agents

بواسطة Gálvez-Peralta, Marina, Hackbarth, Jennifer S., Flatten, Karen S., Kaufmann, Scott H., Hiasa, Hiroshi, Xing, Chenguo, Ferguson, David M.
منشور في 2009

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone

بواسطة Lentz, Sarah R.C., Chheda, Pratik R., Oppegard, Lisa M., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
الحاوية / القاعدة Biochimie (2019)

Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones

بواسطة Oppegard, Lisa M., Streck, Kathryn R., Rosen, Jonathan D., Schwanz, Heidi A., Drlica, Karl, Kerns, Robert J., Hiasa, Hiroshi
منشور في 2010

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

بواسطة Oppegard, Lisa M., Hamann, Bree L., Streck, Kathryn R., Ellis, Keith C., Fiedler, Hans-Peter, Khodursky, Arkady B., Hiasa, Hiroshi
منشور في 2009

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: probing for binding contact with the active site tyrosine of gyrase

بواسطة Towle, Tyrell R., Kulkarni, Chaitanya A., Oppegard, Lisa M., Williams, Bridget P., Picha, Taylor A., Hiasa, Hiroshi, Kerns, Robert J.
الحاوية / القاعدة Bioorg Med Chem Lett (2018)

Anti-proliferative effects of Simocyclinone D8 (SD8), a novel catalytic inhibitor of Topoisomerase II

بواسطة Sadiq, Ahad A., Patel, Manish R., Jacobson, Blake A., Escobedo, Marco, Ellis, Keith, Oppegard, Lisa M., Hiasa, Hiroshi, Kratzke, Robert A.
الحاوية / القاعدة Invest New Drugs (2009)

Probing Structural Requirements for Human Topoisomerase I Inhibition by a Novel N1-Biphenyl Fluoroquinolone

بواسطة Delgado, Justine L., Lentz, Sarah R.C., Kulkarni, Chaitanya A., Chheda, Pratik R., Held, Hailey A., Hiasa, Hiroshi, Kerns, Robert J.
الحاوية / القاعدة Eur J Med Chem (2019)

Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase

بواسطة Aguirre, Arturo L., Chheda, Pratik R., Lentz, Sarah R.C., Held, Hailey A., Groves, Natalie P., Hiasa, Hiroshi, Kerns, Robert J.
الحاوية / القاعدة Bioorg Med Chem (2020)