Replacement of ParC α4 Helix with That of GyrA Increases the Stability and Cytotoxicity of Topoisomerase IV-Quinolone-DNA Ternary Complexes

per Pfeiffer, Emily S., Hiasa, Hiroshi
Publicat 2004

Determination of the Primary Target of a Quinolone Drug and the Effect of Quinolone Resistance-Conferring Mutations by Measuring Quinolone Sensitivity Based on Its Mode of Action

per Pfeiffer, Emily S., Hiasa, Hiroshi
Publicat 2007

Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV–DNA complexes

per Shea, Molly E., Hiasa, Hiroshi
Publicat 2001

Bacillus cereus DNA topoisomerase I and IIIα: purification, characterization and complementation of Escherichia coli TopoIII activity

per Li, Zhiyu, Hiasa, Hiroshi, DiGate, Russell
Publicat 2005

Analysis of Pleiotropic Transcriptional Profiles: A Case Study of DNA Gyrase Inhibition

per Jeong, Kyeong Soo, Xie, Yang, Hiasa, Hiroshi, Khodursky, Arkady B
Publicat 2006

RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli

per Reckinger, Amy R., Jeong, Kyeong Soo, Khodursky, Arkady B., Hiasa, Hiroshi
Publicat 2007

Assessing Sensitivity to Antibacterial Topoisomerase II Inhibitors

per Morgan-Linnell, Sonia K., Hiasa, Hiroshi, Zechiedrich, Lynn, Nitiss, John L.
Publicat 2007

Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl O-Sulfonated Aminoglycoside Derivatives

per Fenner, Amanda M., Oppegard, Lisa M., Hiasa, Hiroshi, Kerns, Robert J.
Publicat 2013

Topoisomerases as Anticancer Targets

per Delgado, Justine L., Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi
Publicat a Biochem J (2018)

Quinolones: Action and Resistance Updated

per Drlica, Karl, Hiasa, Hiroshi, Kerns, Robert, Malik, Muhammad, Mustaev, Arkady, Zhao, Xilin
Publicat 2009

Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones

per Marks, Kevin R., Malik, Muhammad, Mustaev, Arkady, Hiasa, Hiroshi, Drlica, Karl, Kerns, Robert J.
Publicat 2011

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site

per Oppegard, Lisa M., Schwanz, Heidi A., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
Publicat a Biochim Biophys Acta (2015)

On the Role of Topoisomerase I in Mediating the Cytotoxicity of 9-Aminoacridine-Based Anticancer Agents

per Gálvez-Peralta, Marina, Hackbarth, Jennifer S., Flatten, Karen S., Kaufmann, Scott H., Hiasa, Hiroshi, Xing, Chenguo, Ferguson, David M.
Publicat 2009

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone

per Lentz, Sarah R.C., Chheda, Pratik R., Oppegard, Lisa M., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
Publicat a Biochimie (2019)

Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones

per Oppegard, Lisa M., Streck, Kathryn R., Rosen, Jonathan D., Schwanz, Heidi A., Drlica, Karl, Kerns, Robert J., Hiasa, Hiroshi
Publicat 2010

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

per Oppegard, Lisa M., Hamann, Bree L., Streck, Kathryn R., Ellis, Keith C., Fiedler, Hans-Peter, Khodursky, Arkady B., Hiasa, Hiroshi
Publicat 2009

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: probing for binding contact with the active site tyrosine of gyrase

per Towle, Tyrell R., Kulkarni, Chaitanya A., Oppegard, Lisa M., Williams, Bridget P., Picha, Taylor A., Hiasa, Hiroshi, Kerns, Robert J.
Publicat a Bioorg Med Chem Lett (2018)

Anti-proliferative effects of Simocyclinone D8 (SD8), a novel catalytic inhibitor of Topoisomerase II

per Sadiq, Ahad A., Patel, Manish R., Jacobson, Blake A., Escobedo, Marco, Ellis, Keith, Oppegard, Lisa M., Hiasa, Hiroshi, Kratzke, Robert A.
Publicat a Invest New Drugs (2009)

Probing Structural Requirements for Human Topoisomerase I Inhibition by a Novel N1-Biphenyl Fluoroquinolone

per Delgado, Justine L., Lentz, Sarah R.C., Kulkarni, Chaitanya A., Chheda, Pratik R., Held, Hailey A., Hiasa, Hiroshi, Kerns, Robert J.
Publicat a Eur J Med Chem (2019)

Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase

per Aguirre, Arturo L., Chheda, Pratik R., Lentz, Sarah R.C., Held, Hailey A., Groves, Natalie P., Hiasa, Hiroshi, Kerns, Robert J.
Publicat a Bioorg Med Chem (2020)