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Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl O-Sulfonated Aminoglycoside Derivatives

[Image: see text] Numerous therapeutic applications have been proposed for molecules that bind heparin-binding proteins. Development of such compounds has primarily focused on optimizing the degree and orientation of anionic groups on a scaffold, but utility of these polyanions has been diminished b...

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Autori principali: Fenner, Amanda M., Oppegard, Lisa M., Hiasa, Hiroshi, Kerns, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694624/
https://ncbi.nlm.nih.gov/pubmed/23814643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3004507
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