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Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles
Hoechst dyes are well known DNA binders that non-selectively inhibit the function of mammalian topoisomerase I and II. Herein, we show that Hoechst 33258 based bisbenzimidazoles (DPA 151–154), containing a terminal alkyne, are effective and selective inhibitors of E. coli. topoisomerase I. These bis...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112416/ https://ncbi.nlm.nih.gov/pubmed/25083189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00140K |
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