Novel N-1 Substituted Fluoroquinolones Inhibit Human Topoisomerase I Activity and Exhibit Anti-proliferative Activity

Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that target eukaryotic type IIA topoisomerases. Fluoroquinolones bind and stabilize type IIA topoisomerase-DNA covalent complexes that contain a double-strand...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Invest New Drugs
Prif Awduron: Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R.C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409185/
https://ncbi.nlm.nih.gov/pubmed/30198058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0666-x
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