The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone

por Lentz, Sarah R.C., Chheda, Pratik R., Oppegard, Lisa M., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi
Publicado no Biochimie (2019)

Probing Structural Requirements for Human Topoisomerase I Inhibition by a Novel N1-Biphenyl Fluoroquinolone

por Delgado, Justine L., Lentz, Sarah R.C., Kulkarni, Chaitanya A., Chheda, Pratik R., Held, Hailey A., Hiasa, Hiroshi, Kerns, Robert J.
Publicado no Eur J Med Chem (2019)

Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase

por Aguirre, Arturo L., Chheda, Pratik R., Lentz, Sarah R.C., Held, Hailey A., Groves, Natalie P., Hiasa, Hiroshi, Kerns, Robert J.
Publicado no Bioorg Med Chem (2020)

Novel N-1 Substituted Fluoroquinolones Inhibit Human Topoisomerase I Activity and Exhibit Anti-proliferative Activity

por Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R.C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi
Publicado no Invest New Drugs (2018)