Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV–DNA complexes
Some topoisomerase inhibitors trap covalent topoisomerase–DNA complexes as topoisomerase–drug–DNA ternary complexes. Ternary complex formation results in inhibition of DNA replication and generation of permanent double-strand breaks. Recent demonstrations of the stimulation of covalent topoisomerase...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30393/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.3.614 |
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