Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV–DNA complexes

Some topoisomerase inhibitors trap covalent topoisomerase–DNA complexes as topoisomerase–drug–DNA ternary complexes. Ternary complex formation results in inhibition of DNA replication and generation of permanent double-strand breaks. Recent demonstrations of the stimulation of covalent topoisomerase...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Shea, Molly E., Hiasa, Hiroshi
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30393/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.3.614
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