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Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino gr...

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Bibliographic Details
Main Authors: German, Nadezhda, Malik, Muhammad, Rosen, Jonathan D., Drlica, Karl, Kerns, Robert J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573108/
https://ncbi.nlm.nih.gov/pubmed/18765690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00330-08
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