Cleavable-Complex Formation by Wild-Type and Quinolone-Resistant Streptococcus pneumoniae Type II Topoisomerases Mediated by Gemifloxacin and Other Fluoroquinolones

Gemifloxacin is a recently developed fluoroquinolone with potent activity against Streptococcus pneumoniae. We show that the drug is more active than moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin against S. pneumoniae strain 7785 (MICs, 0.03 to 0.06 μg/ml versus 0.25, 0.25, 1, and 1 to...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Yague, Genoveva, Morris, Julia E., Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.413-419.2002
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