Cleavable-Complex Formation by Wild-Type and Quinolone-Resistant Streptococcus pneumoniae Type II Topoisomerases Mediated by Gemifloxacin and Other Fluoroquinolones

Gemifloxacin is a recently developed fluoroquinolone with potent activity against Streptococcus pneumoniae. We show that the drug is more active than moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin against S. pneumoniae strain 7785 (MICs, 0.03 to 0.06 μg/ml versus 0.25, 0.25, 1, and 1 to...

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發表在:	Antimicrob Agents Chemother
Principais autores:	Yague, Genoveva, Morris, Julia E., Pan, Xiao-Su, Gould, Katherine A., Fisher, L. Mark
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2002
主題:	Mechanisms of Resistance
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.413-419.2002
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