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Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase
Type II topoisomerases alter DNA topology to control DNA supercoiling and chromosome segregation and are targets of clinically important anti-infective and anticancer therapeutics. They act as ATP-operated clamps to trap a DNA helix and transport it through a transient break in a second DNA. Here, w...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030046/ https://ncbi.nlm.nih.gov/pubmed/29968711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05005-x |
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