Breakage-Reunion Domain of Streptococcus pneumoniae Topoisomerase IV: Crystal Structure of a Gram-Positive Quinolone Target

The 2.7 Å crystal structure of the 55-kDa N-terminal breakage-reunion domain of topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the quinolone targets from a gram-positive bacterium, has been solved and reveals a ‘closed’ dimer similar in fold to Escherichia coli...

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Detalhes bibliográficos
Main Authors: Laponogov, Ivan, Veselkov, Dennis A., Sohi, Maninder K., Pan, Xiao-Su, Achari, Aniruddha, Yang, Cheng, Ferrara, Joseph D., Fisher, L. Mark, Sanderson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810434/
https://ncbi.nlm.nih.gov/pubmed/17375187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000301
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