Attacking Cancer’s Achilles Heel: Antagonism of Anti-Apoptotic BCL-2 Family Members

by Opferman, Joseph T.
Published in FEBS J (2015)

Anti-apoptotic BCL-2 family members in development

by Opferman, Joseph T, Kothari, Anisha
Published in Cell Death Differ (2018)

Delving Deeper: MCL-1's Contributions to Normal and Cancer Biology

by Perciavalle, Rhonda M., Opferman, Joseph T.
Published 2012

CONTRACTING THE ‘MUS CELLS’ – DOES DOWN-SIZING SUIT US FOR DIVING INTO THE MEMORY POOL ?

by Kurtulus, Sema, Tripathi, Pulak, Opferman, Joseph T., Hildeman, David A.
Published 2010

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

by Delbridge, Alex R. D., Opferman, Joseph T., Grabow, Stephanie, Strasser, Andreas
Published in Blood (2015)

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

by Brunelle, Joslyn K., Ryan, Jeremy, Yecies, Derek, Opferman, Joseph T., Letai, Anthony
Published 2009

Proapoptotic BAX and BAK control multiple initiator caspases

by Ruiz-Vela, Antonio, Opferman, Joseph T, Cheng, Emily H-Y, Korsmeyer, Stanley J
Published 2005

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

by Villalobos-Ortiz, Mariana, Ryan, Jeremy, Mashaka, Thelma N., Opferman, Joseph T., Letai, Anthony
Published in Cell Death Differ (2019)

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice

by van Oosterwijk, Jolieke G., Li, Chunliang, Yang, Xue, Opferman, Joseph T., Sherr, Charles J.
Published in Proc Natl Acad Sci U S A (2017)

The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis

by Flemmer, Robert T., Connolly, Sarah P., Geizer, Brittany A., Opferman, Joseph T., Vanderluit, Jacqueline L.
Published in Front Cell Dev Biol (2021)

Ubiquitin-Independent Degradation of Antiapoptotic MCL-1

by Stewart, Daniel P., Koss, Brian, Bathina, Madhavi, Perciavalle, Rhonda M., Bisanz, Kristen, Opferman, Joseph T.
Published 2010

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

by Steimer, Desiree A., Boyd, Kelli, Takeuchi, Osamu, Fisher, Jill K., Zambetti, Gerard P., Opferman, Joseph T.
Published 2009

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia

by Koss, Brian, Morrison, Jeffrey, Perciavalle, Rhonda M., Singh, Harpreet, Rehg, Jerold E., Williams, Richard T., Opferman, Joseph T.
Published 2013

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

by Oakes, Scott A., Scorrano, Luca, Opferman, Joseph T., Bassik, Michael C., Nishino, Mari, Pozzan, Tullio, Korsmeyer, Stanley J.
Published 2005

GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis

by Sano, Renata, Annunziata, Ida, Patterson, Annette, Moshiach, Simon, Gomero, Elida, Opferman, Joseph, Forte, Michael, d'Azzo, Alessandra
Published 2009

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

by Xiang, Zhifu, Luo, Hui, Payton, Jacqueline E., Cain, Jennifer, Ley, Timothy J., Opferman, Joseph T., Tomasson, Michael H.
Published 2010

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability

by Ah-Cann, Casey, Tailler, Maximilien, Kueh, Andrew J, Herold, Marco J, Opferman, Joseph T, Asselin-Labat, Marie-Liesse, Bouillet, Philippe
Published in Cell Death Dis (2016)

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system

by Fogarty, Lauren C., Flemmer, Robert T., Geizer, Brittany A., Licursi, Maria, Karunanithy, Ahila, Opferman, Joseph T., Hirasawa, Kensuke, Vanderluit, Jacqueline L.
Published in Cell Death Differ (2018)

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

by Germain, Marc, Nguyen, Angela P, Le Grand, J Nicole, Arbour, Nicole, Vanderluit, Jacqueline L, Park, David S, Opferman, Joseph T, Slack, Ruth S
Published 2011

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

by Wang, Xi, Bathina, Madhavi, Lynch, John, Koss, Brian, Calabrese, Christopher, Frase, Sharon, Schuetz, John D., Rehg, Jerold E., Opferman, Joseph T.
Published 2013