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BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

Inhibition of the anti-apoptotic machinery of cancer cells is a promising therapeutic approach that has driven the development of an important class of compounds termed “BH3 mimetics”. These novel small molecules mimic BH3-only proteins by antagonizing the pro-survival function of anti-apoptotic pro...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Villalobos-Ortiz, Mariana, Ryan, Jeremy, Mashaka, Thelma N., Opferman, Joseph T., Letai, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205860/
https://ncbi.nlm.nih.gov/pubmed/31332296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0391-9
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