GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis

Mitochondria-associated ER membranes or MAMs define the sites of endoplasmic reticulum/mitochondria juxtaposition that control Ca(2+) flux between these organelles. We found that in a mouse model of the human lysosomal storage disease GM1-gangliosidosis, GM1-ganglioside accumulates in the glycosphin...

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Main Authors: Sano, Renata, Annunziata, Ida, Patterson, Annette, Moshiach, Simon, Gomero, Elida, Opferman, Joseph, Forte, Michael, d'Azzo, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782904/
https://ncbi.nlm.nih.gov/pubmed/19917257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.021
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