Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic reticulum (ER) Ca(2+) stores necessary for Ca(2+)-dependent cell death. Conversely, antiapoptotic BCL-2 has been shown to decrease Ca(2+) co...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Oakes, Scott A., Scorrano, Luca, Opferman, Joseph T., Bassik, Michael C., Nishino, Mari, Pozzan, Tullio, Korsmeyer, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544078/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15613488/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408352102
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