Bimodal degradation of MLL by SCF(Skp2) and APC(Cdc20) assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

Por Liu, Han, Cheng, Emily H.-Y., Hsieh, James J.-D.
Publicado em 2007

Proapoptotic BAX and BAK control multiple initiator caspases

Por Ruiz-Vela, Antonio, Opferman, Joseph T, Cheng, Emily H-Y, Korsmeyer, Stanley J
Publicado em 2005

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

Por Chen, Yun, Lewis, William, Diwan, Abhinav, Cheng, Emily H.-Y., Matkovich, Scot J., Dorn, Gerald W.
Publicado em 2010

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

Por Cheng, Emily H.-Y., Nicholas, John, Bellows, David S., Hayward, Gary S., Guo, Hong-Guang, Reitz, Marvin S., Hardwick, J. Marie
Publicado em 1997

Phosphorylation of MLL by ATR is Required for Execution of Mammalian S Phase Checkpoint

Por Liu, Han, Takeda, Shugaku, Kumar, Rakesh, Westergard, Todd D., Brown, Eric J., Pandita, Tej K., Cheng, Emily H.-Y., Hsieh, James J.-D.
Publicado em 2010

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

Por Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana
Publicado em 2011

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

Por Kim, Hyungjin, Tu, Ho-Chou, Ren, Decheng, Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Publicado em 2009

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

Por Pavlov, Evgeny V., Priault, Muriel, Pietkiewicz, Dawn, Cheng, Emily H.-Y., Antonsson, Bruno, Manon, Stephen, Korsmeyer, Stanley J., Mannella, Carmen A., Kinnally, Kathleen W.
Publicado em 2001

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

Por Tu, Ho-Chou, Ren, Decheng, Wang, Gary X., Chen, David Y., Westergard, Todd D., Kim, Hyungjin, Sasagawa, Satoru, Hsieh, James J.-D., Cheng, Emily H.-Y.
Publicado em 2009

Taspase1 Functions as a Non-oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

Por Chen, David Y., Liu, Han, Takeda, Shugaku, Tu, Ho-Chou, Sasagawa, Satoru, Van Tine, Brian A., Lu, Dongsi, Cheng, Emily H.-Y., Hsieh, James J.-D.
Publicado em 2010

The VDAC2-BAK Rheostat Controls Thymocyte Survival

Por Ren, Decheng, Kim, Hyungjin, Tu, Ho-Chou, Westergard, Todd D., Fisher, Jill K., Rubens, Jeff A., Korsmeyer, Stanley J., Hsieh, James J.-D., Cheng, Emily H.-Y.
Publicado em 2009

Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression

Por Takeda, Shugaku, Chen, David Y., Westergard, Todd D., Fisher, Jill K., Rubens, Jeffrey A., Sasagawa, Satoru, Kan, Jason T., Korsmeyer, Stanley J., Cheng, Emily H.-Y., Hsieh, James J.-D.
Publicado em 2006

BAX Activation is Initiated at a Novel Interaction Site

Por Gavathiotis, Evripidis, Suzuki, Motoshi, Davis, Marguerite L., Pitter, Kenneth, Bird, Gregory H., Katz, Samuel G., Tu, Ho-Chou, Kim, Hyungjin, Cheng, Emily H.-Y., Tjandra, Nico, Walensky, Loren D.
Publicado em 2008

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

Por Ren, Decheng, Tu, Ho-Chou, Kim, Hyungjin, Wang, Gary X., Bean, Gregory R., Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Publicado em 2010

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Por Wei, Michael C., Zong, Wei-Xing, Cheng, Emily H. -Y., Lindsten, Tullia, Panoutsakopoulou, Vily, Ross, Andrea J., Roth, Kevin A., MacGregor, Grant R., Thompson, Craig B., Korsmeyer, Stanley J.
Publicado em 2001

PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis

Por Bean, Gregory R., Ganesan, Yogesh Tengarai, Dong, Yiyu, Takeda, Shugaku, Liu, Han, Chan, Po M., Huang, Yafen, Chodosh, Lewis A., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.
Publicado em 2013

Modulation of cell death by Bcl-x(L) through caspase interaction

Por Clem, Rollie J., Cheng, Emily H.-Y., Karp, Christopher L., Kirsch, David G., Ueno, Kazuyoshi, Takahashi, Atsushi, Kastan, Michael B., Griffin, Diane E., Earnshaw, William C., Veliuona, Michael A., Hardwick, J. Marie
Publicado em 1998

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

Por Karch, Jason, Kwong, Jennifer Q, Burr, Adam R, Sargent, Michelle A, Elrod, John W, Peixoto, Pablo M, Martinez-Caballero, Sonia, Osinska, Hanna, Cheng, Emily H-Y, Robbins, Jeffrey, Kinnally, Kathleen W, Molkentin, Jeffery D
Publicado em 2013

A Pharmacological Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

Por Chen, David Y., Lee, Yishan, Van Tine, Brian A., Searleman, Adam C., Westergard, Todd D., Liu, Han, Tu, Ho-Chou, Takeda, Shugaku, Dong, Yiyu, Piwnica-Worms, David R., Oh, Kyoung J., Korsmeyer, Stanley J., Hermone, Ann, Gussio, Richard, Shoemaker, Robert H., Cheng, Emily H.-Y., Hsieh, James J.-D.
Publicado em 2011