A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

Genomic instability due to telomere dysfunction and defective repair of DNA double-strand breaks (DSBs) is an underlying cause of ageing-related diseases. 53BP1 is a key factor in DNA DSBs repair and its deficiency is associated with genomic instability and cancer progression. Here, we uncover a nov...

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Bibliografiske detaljer
Main Authors: Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160650/
https://ncbi.nlm.nih.gov/pubmed/21750527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.225
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