Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability

Over 300 mutations in the LMNA gene, encoding A-type lamins, are associated with 15 human degenerative disorders and premature aging syndromes. Although genomic instability seems to contribute to the pathophysiology of some laminopathies, there is limited information about what mutations cause genom...

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Hlavní autoři: Das, Arindam, Grotsky, David A, Neumann, Martin A, Kreienkamp, Ray, Gonzalez-Suarez, Ignacio, Redwood, Abena B, Kennedy, Brian K, Stewart, Colin L, Gonzalo, Susana
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899131/
https://ncbi.nlm.nih.gov/pubmed/24153156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.26873
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