BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript and protein levels in tumors remain unknown. Here, we demonstrate that BRCA1 loss...

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Detalhes bibliográficos
Main Authors: Grotsky, David A., Gonzalez-Suarez, Ignacio, Novell, Anna, Neumann, Martin A., Yaddanapudi, Sree C., Croke, Monica, Martinez-Alonso, Montserrat, Redwood, Abena B., Ortega-Martinez, Sylvia, Feng, Zhihui, Lerma, Enrique, Ramon y Cajal, Teresa, Zhang, Junran, Matias-Guiu, Xavier, Dusso, Adriana, Gonzalo, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549967/
https://ncbi.nlm.nih.gov/pubmed/23337117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201204053
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