Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells

BRCA1 and 53BP1 play decisive roles in the choice of DNA double-strand break repair mechanisms. BRCA1 promotes DNA end resection and homologous recombination (HR) during S/G(2) phases of the cell cycle, while 53BP1 inhibits end resection and facilitates non-homologous end-joining (NHEJ), primarily d...

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Main Authors: Croke, Monica, Neumann, Martin A, Grotsky, David A, Kreienkamp, Ray, Yaddanapudi, Sree C, Gonzalo, Susana
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903714/
https://ncbi.nlm.nih.gov/pubmed/24091731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26582
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