Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a “BH3-domain–only” BCL-2 family member, triggers the homooligomerization of “multidomain” conserved proapopto...

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Autori principali: Wei, Michael C., Zong, Wei-Xing, Cheng, Emily H. -Y., Lindsten, Tullia, Panoutsakopoulou, Vily, Ross, Andrea J., Roth, Kevin A., MacGregor, Grant R., Thompson, Craig B., Korsmeyer, Stanley J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049805/
https://ncbi.nlm.nih.gov/pubmed/11326099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1059108
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